Any good schedule needs balance. You could go the Wainwright route, which I believe in 2004 UR had a top 10 OOC schedule with games at Kansas, at Colorado, at UAB, neutral game with South Carolina, at Wake, neutral game with Manhattan, at South Florida. But few people remember - UR entered A10 play that year with a record of 7-5 and entered the Kansas road trip of at Temple, at Kansas, and at Xavier at 8-8. UR was not even in the discussion at that point for an NCAA bid. So it was a total gamble with that schedule. Luckily - they pulled out 3 wins - came out to 11-8 and finished the A10 strong.
But I think the more typical approach these days, unless your a Michigan state who knows they will make the tourney each and every year - is you have to be strategic with your scheduling. You need a handful of easy games - probably quad 3-4 games, and likely at home. Then you need a some quad 2 games with other mid-majors or low level P5 schools. These should be teams expected to win their conference from mid-level conferences, or schools expected to be on the bubble from P5 levels. Then you need 2-3 strong quad 1 games. These will likely be road games or tourney games on neutral sites. Your looking to steal 1 of these games. Think games like Purdue, Missouri, or Florida from the Mooney NCAA runs. You don't expect to win all of these games - but if you play 2-3 of them in your OOC, you steal 1 of them - your looking good.
There has been much debate on the schedule on this board, and I frankly don't have an issue with it. Its clearly not the best schedule in school history. But it is good enough to do 2 things. 1) Save Mooney's job. Your crazy if you don't think coaches consider this when putting together schedules. They need to win games at the end of the day. 2) Keeps UR in the NCAA conversation, if they win the games they should - which is what UR has done and maybe even stolen a game with Wisconsin (depends on how Wisconsin fairs in Big Ten).
But overall - the spiders will need to close out the OOC strong, ideally winning at least 2 if not all 3 of the remaining games. Then will still need to finish the A10 in the top 3. Which based on what we have seen so far from them - is still a possibility.