It happens all over the place. Did you see VT Miami last night? VT was up 17 with 15 minutes left, still up 13 with 10 minutes left, up 9 with 1:30 left and won by 2 after Miami missed a shot at the end. Miami made 5 3s in the final 10 minutes. It happens. Teams often get hot after being cold early.
How about VCU JMU? VCU up 20 with 10 minutes left and still up 13 with 4 minutes left? Safe? Not at all. JMU went on a 10-0 run ( 25-8 run since the 10 minute mark) to make it a 3 point game with 1:30 left, and lost by 1.